Aging is more deadly than cancer. We treat cancer with chemotherapy. We need to treat aging with meds.
Long on Meds
Live longer by avoiding and reversing disease.
Long on Meds shows how optimal combinations of generic medications can help with disease avoidance and regression. They also have the most evidence for extending longevity. The same medications, by suppressing inflammation, may help slow or reverse the muscle loss of aging.
- A large part of visible aging is sarcopenia — the gradual loss of muscle mass, strength, and physical reserve.
- Chronic inflammation helps drive many changes associated with aging, including muscle loss, frailty, slower recovery, and vascular and metabolic disease.
- Long on Meds has analyzed more than 130 commonly prescribed generic medications. The research shows how carefully selected combinations may reduce activity across three major inflammatory pathways.
- The goal is disease avoidance and regression, while preserving muscle and physical reserve. Live long by not dying.
Physical reserve is the goal.
Disease avoidance. Disease regression. Published pathway evidence. Physician-guided discussion.
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How to Use Long on Meds
Evaluate your conditions and current medications, identify potentially better choices, and take the results to your doctor.
Self-checkMuscle Reserve Check
Answer five functional questions and use the 30-second chair stand test as an objective modifier. Both tests are based on scientifically validated screening tools.
Medication lookupCheck up to five medications
See whether selected medications have evidence of activity in NF-κB, NLRP3, and oxidative stress pathways.
Evidence-Based Answers on Healthy Aging
What Are the Three Inflammaging Pathways?
Learn how cytokine signaling, inflammasome activity, and oxidative stress contribute to chronic inflammatory pressure.
Long on MedsWhy Does Muscle Reserve Matter for Healthy Aging?
Muscle reserve supports mobility, independence, glucose control, vascular health, and recovery from illness or injury.
Long on MedsWhy Is Disease Avoidance the Most Proven Longevity Strategy?
There are no proven human longevity drugs, but preventing and reversing disease has the strongest evidence for extending life.
Long on MedsCan Generic Medications Be Repurposed to Reduce Inflammatory Pressure?
Some generic medications have anti-inflammatory pathway effects beyond their original prescribing purpose.
Long on MedsCan Common Medications Really Slow Aging?
New research on Aging Rate Indicators suggests that some established medications may influence biological pathways associated with slower aging.
Long on MedsHow Well Should My Blood Pressure Medications Control My Hypertension?
For most adults with hypertension, treatment should aim below 130/80. Learn why tighter control and thoughtful medication selection matter.
Long on MedsCan Low-Dose Doxycycline Help Protect My Joints From Osteoarthritis?
Human evidence suggests doxycycline can slow structural knee deterioration, while low doses retain tissue-modifying effects.
Long on MedsCan Low-Dose Colchicine Help Protect Against Cardiovascular Disease?
Large randomized trials show that low-dose colchicine can reduce cardiovascular events, leading to an FDA-approved cardiovascular indication.
Long on MedsCan Low-Dose Naltrexone Help Protect My Brain?
LDN has plausible effects on neuroinflammation, encouraging animal evidence, preliminary human CNS signals, and generally favorable low-dose tolerability.
Long on MedsShould I Stay on a GLP-1 Drug After I Reach a Healthy Weight?
Weight maintenance is only part of the question as evidence grows for broader metabolic, inflammatory, cardiovascular, and organ effects.
Long on MedsCan Common Medications Help Lower the Risk of Alzheimer’s Disease?
New research raises questions about the immune system, common medications, and whether combining metformin with a GLP-1 drug may be linked with lower Alzheimer’s risk.
Long on MedsWhy Do Our Muscles Lose Power as We Age?
New research identifies a mitochondrial change that may help explain why aging muscles lose strength and points toward possible future treatments.
Long on MedsAdditional Evidence: Could Generic Medications Help Treat Alzheimer’s Disease?
New research on generic HIV medications, including lamivudine, suggests possible benefits for brain inflammation and neurological protection. Early findings also raise questions about multiple sclerosis.
Long on MedsWhat Commonly Used Medications Are Most Effective at Suppressing Chronic Inflammation?
Can familiar medications reduce chronic inflammation? Explore six medications, including colchicine, rosuvastatin, and low dose doxycycline, and what human studies reveal.
Long on MedsDoes the Scientific Evidence Support That Common Medications Suppress Inflammation?
What laboratory research reveals about how colchicine, doxycycline, rosuvastatin, and other medications interfere with inflammatory pathways.
Long on MedsCan Suppressing Inflammation Promote Healthy Aging?
Can reducing chronic inflammation protect our muscles, heart, brain, and kidneys? Explore what human clinical trials reveal about healthier aging.
Evidence library
The References and Evidence Library organizes the supporting literature by medication class, pathway biology, inflammaging, sarcopenia, and the Muscle Reserve Check.
Review the evidence library